Classical pathway complement activation ppt

Immunological tolerance. Related Books Free with a 30 day trial from Scribd. Elizabeth Howell. Related Audiobooks Free with a 30 day trial from Scribd. On Animals Susan Orlean. Pastoral Song James Rebanks. A Wild Idea Jonathan Franklin. The complement system 1. Biotech 2nd sem Dept. The components of complement system 6. Biological activity Unique proteins for 1st 2 steps common proteins 8. Ab binding to the pathogen.

C1 proteins binds to the Fc of Ab. Staple structure of IgM At least 3 binding sited for C1q are exposed. Cleavage of C3 reveals a thioester bond and it will bind to cell surface of pathogen. Pathogen Pathogen C3b C3b is an opsonin Opsonins are molecules that bind both to bacteria and phagocytes Opsonization increases phagocytosis by 1, fold. C3b s attached to microbial surface microbe C6 Cell membrane Pathogen Cell membrane Pathogen C7 Cell membrane Cell membrane Pathogen C8 Cell membrane Pathogen C9 Cell membrane Pathogen Neutrophil Macrophage Granules containing inflammato ry agents like histamine May cleave over a million C3 molecules!

Figure 1. Complement pathways. Bitesize category Systems and Processes. Related Articles T Lymphocyte Transmigration. T-cell activation. Reproductive immunology: immunology of pregnancy.

Dendritic Cells: Migration. Complement System. Co-Receptors: Function. Antigen Processing and Presentation. Translate PDF. I customized them from electronic books and sites. Sheep antiserum to the bacterium Vibrio cholerae caused lysis of the bacteria. Heating the antiserum destroyed its bacteriolytic activity. Addition of fresh normal serum, that contained no Abs against the bacterium and was unable to kill the bacterium by itself, restored the ability to lyse the bacteria by the heated antiserum.

Q1: If you were Bordet, what would you hypothesize? A1: Bacteriolytic activity requires 2 different substances. The Functions of Complement 1.

Lysis of cells, bacteria, and viruses — the major effector of the humoral branch of the immune system 2. Opsonization, which promotes phagocytosis of particulate Ags 3. Binding to specific complement receptors on cells of the immune system, triggering specific cell functions, inflammation, and secretion of immunoregulatory molecules 4. Classical Pathway — begins with the formation of Ag-Ab complex 2.